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Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
Gout (/ ɡ aʊ t / GOWT [7]) is a form of inflammatory arthritis characterized by recurrent attacks of pain in a red, tender, hot, and swollen joint, [2] [8] caused by the deposition of needle-like crystals of uric acid known as monosodium urate crystals. [9]
Severe side effects include brain dysfunction, low blood cell counts, and lung inflammation. [3] Use in pregnancy will likely result in harm to the fetus. [ 3 ] Fludarabine is in the purine analog family of medications and works by interfering with the duplication of DNA .
The major side effects of tegafur are similar to fluorouracil and include myelosuppression, central neurotoxicity and gastrointestinal toxicity (especially diarrhoea). [3] Gastrointestinal toxicity is the dose-limiting side effect of tegafur. [3] Central neurotoxicity is more common with tegafur than with fluorouracil. [3]
FOL – folinic acid (leucovorin), a vitamin B derivative that modulates/potentiates/reduces the side effects of fluorouracil; F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates into the DNA molecule and stops DNA synthesis;
Common side effects include bone marrow suppression, loss of appetite, diarrhea, vomiting, and psychosis. [2] Anaphylaxis and other allergic reactions occasionally occur. [2] It is unclear if use in pregnancy is safe for the baby. [4] Flucytosine is in the fluorinated pyrimidine analogue family of medications. [2]
(Note: Red dye No.3 has not been proven to cause cancer in humans, despite what you may have read on social media.) While many companies have been phasing out use of red dye No.3 for years, some ...
UFT is an oral formulation combining uracil (a competitive inhibitor of dihydropyrimidine dehydrogenase), and tegafur (a bioavailable 5-fluorouracil (5-FU) prodrug) in a 4:1 molar ratio. [ 1 ] Uracil has also been stated to help protect the gastrointestinal tract from 5-FU toxicity and the related metabolites, with less side effects than 5-FU ...