Search results
Results from the WOW.Com Content Network
Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products. Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone . [ 9 ]
A partial list includes brown sugar, sugar, corn syrup, canola oil, dextrose, high fructose corn syrup, modified food starch, polysorbate 80, smoke flavor, sodium benzoate (as a preservative), and ...
When used in the extemporaneous preparation of topical medications, it is supplied in the form of coal tar topical solution USP, which consists of a 20% w/v solution of coal tar in alcohol, with an additional 5% w/v of polysorbate 80 USP; this must then be diluted in an ointment base, such as petrolatum.
Polysorbate 60 (polyoxyethylene (20) sorbitan monostearate) Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate) The number following the 'polysorbate' part is related to the type of major fatty acid associated with the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80.
Coating these polymeric nanoparticle devices with different surfactants can also aid BBB crossing and uptake in the brain. Surfactants such as polysorbate 80, 20, 40, 60, and poloxamer 188, demonstrated positive drug delivery through the blood–brain barrier, whereas other surfactants did not yield the same results. [2]
Examples synthesized on an industrial scale include octyl phenol ethoxylate, polysorbate 80 and poloxamers. Ethoxylation is commonly practiced, albeit on a much smaller scale, in the biotechnology and pharmaceutical industries to increase water solubility and, in the case of pharmaceuticals, circulatory half-life of non-polar organic compounds.
Decyl glucoside is a mild non-ionic surfactant used in cosmetic formularies, [1] including baby shampoo and in products for individuals with a sensitive skin. Many natural personal care companies use this cleanser because it is plant-derived, biodegradable, and gentle for all hair types.
Cinnamon oil nanoemulsion can be made with polysorbate 80, cinnamon essential oil, and water, by ultrasonic emulsification. [55] [56] Cinnamon oil macroemulsion can be made with a dispersing emulsifying homogenizer. [56] [57] The pungent taste and scent come from cinnamaldehyde, about 90% of the essential oil from cinnamon bark. [58]