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Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction , thus causing flaccid paralysis . [ 25 ]
Allergan plc is an American, Irish-domiciled pharmaceutical company that acquires, develops, manufactures and markets brand name drugs and medical devices in the areas of medical aesthetics, eye care, central nervous system, and gastroenterology. [1] [2] [3] The company is the maker of Botox. [1]
BAT is the only FDA-approved product available for treating botulism in adults, and for botulism in infants caused by botulinum toxins other than types A and B. BAT has been used to treat a case of type F infant botulism and, on a case-by-case basis, may be used for future cases of non-type A and non-type B infant botulism.
Merz Pharma GmbH & Co. KGaA (also Merz Pharma KGaA or Merz) is an internationally active family-owned company, headquartered in Frankfurt am Main, Germany.Merz is the parent company of independent businesses in the fields of aesthetic medicine, therapeutic medicine (including for neurological movement disorders), and wellness and beauty products with its brands Tetesept [1] and Merz Spezial.
Most Americans would prefer brand-name drugs—but end up buying generic versions because of the cost, new consumer research suggests. Gen Z’s expensive drug habit: More want brand-name meds ...
This generally only occurs with inappropriate strengths of botulinum toxin for cosmetic use or due to the larger doses used to treat movement disorders. [2] However, there are cases where an off-label use of botulinum toxin resulted in severe botulism and death. [25] Following a 2008 review the FDA added these concerns as a boxed warning. [26]
In November 2021, Galderma bought California-based Alastin, a firm specialising in specialist skincare products, for an undisclosed price. [5] [12] In June 2022, Galderma announced positive results in two Phase III trials for liquid botulinum toxin A, showing RelabotulinumtoxinA was well tolerated.
Torticollis patients discovered that their pain could be markedly reduced, motility increased, and head position improved by toxin injection. But, in 1986, Oculinum Inc, Scott's micromanufacturer and distributor of botulinum toxin, was unable to obtain product liability insurance, and could no longer supply the drug.