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The aims of EULAR are to reduce the burden of rheumatic diseases on the individual and society and to improve the treatment, prevention and rehabilitation of musculoskeletal diseases. It promotes the translation of research advances into daily care and fights for the recognition of the needs of people with musculoskeletal diseases by the ...
Sifalimumab is a human monoclonal antibody designed for the treatment of SLE, dermatomyositis, and polymyositis. [1] It targets interferon a. [2] Sifalimumab was developed by MedImmune; as of 2017 development had been terminated in favor of moving a competing internal product, anifrolumab, into Phase III trials. [3] [4] [5]
Epratuzumab binds to the glycoprotein CD22 of mature and malignant B-cells.. Elevated CD22 and other B-cell receptor (BCR) proteins are associated with SLE. "Epratuzumab's mechanism of action transfers these BCR proteins to helper cells called effector cells which reduces B-cell destruction and epratuzumab's impact on the body's immune system" [6] via a process called trogocytosis. [3]
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE) and childhood-onset systemic lupus erythematosus which is a more severe form of SLE that develops in children up to 18 years old; both are autoimmune diseases. [3] [4] It is a type of glomerulonephritis in which the glomeruli become inflamed.
Dracunculiasis, or Guinea worm disease, is an infection by the Guinea worm that causes severe pain and open wounds when guinea worms exit the body through the skin. [1] In 1986, there were an estimated 3.5 million cases of Guinea worm in 20 endemic nations in Asia and Africa. [ 2 ]
The computation of (1 + iπ / N ) N is displayed as the combined effect of N repeated multiplications in the complex plane, with the final point being the actual value of (1 + iπ / N ) N. It can be seen that as N gets larger (1 + iπ / N ) N approaches a limit of −1. Euler's identity asserts that is
SLE skipped over versions 13 and 14, realigning the versions of openSUSE Leap and SLE at version 15. SLE 15 was released June 25, 2018 with the same codebase as openSUSE Leap 15.0. SLED 15 included major upgrades to GNOME 3.26, LibreOffice 6.0, GCC 7 and LTS kernel version 4.12. Version 15 also made the Wayland implementation of GNOME the ...
The LE cell was discovered in bone marrow in 1948 by Malcolm McCallum Hargraves (1903–1982), a physician and practicing histologist at the Mayo Clinic. [5] Hargraves may have gained priority by suppressing a publication draft of John R. Haserick, who credits Dorothy Sundberg, chief hematologist at the University of Minnesota Hospitals, with ...