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  2. Duloxetine - Wikipedia

    en.wikipedia.org/wiki/Duloxetine

    Duloxetine, administered in a single oral dose of 20 mg or 40 mg has plasma elimination half-life of 10–12 h [9] [4] and its pharmacokinetics are dose proportional over the therapeutic range. [4] Steady-state concentration is usually achieved after 3 days.

  3. Serotonin–norepinephrine reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    The half-life of desvenlafaxine is about 11 hours, and steady-state concentrations are achieved after 4 to 5 days. [58] The half-life of duloxetine is about 12 hours (range: 8–17 hours), and steady-state is achieved after about 3 days. [11] Milnacipran has a half-life of about 6 to 8 hours, and steady-state levels are reached within 36 to 48 ...

  4. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    Mercury (as methylmercury) in the body has a half-life of about 65 days. Lead in the blood has a half life of 28–36 days. [29] [30] Lead in bone has a biological half-life of about ten years. Cadmium in bone has a biological half-life of about 30 years. Plutonium in bone has a biological half-life of about 100 years.

  5. Switching Antidepressants: Safety, Side Effects & Other ... - AOL

    www.aol.com/switching-antidepressants-safety...

    For medications with a shorter half-life, you might only have to wait two to four days before you begin using the new antidepressant at a low dose. There’s no one-size-fits-all process for ...

  6. Duloxetine antidepressant recalled over presence of toxic ...

    www.aol.com/news/duloxetine-antidepressant...

    Some bottles of the antidepressant duloxetine, sold under the brand name Cymbalta, were recalled due to the presence of a toxic chemical.

  7. FDA recalls over 7,000 bottles of antidepressant due to ...

    www.aol.com/news/fda-recalls-over-7-000...

    The Food and Drug Administration has announced a recall for thousands of bottles of the antidepressant duloxetine, sold under brand names like Cymbalta, due to the presence of a chemical that can ...

  8. Antidepressant discontinuation syndrome - Wikipedia

    en.wikipedia.org/wiki/Antidepressant...

    There is also evidence that antidepressant discontinuation syndrome may be related to the biological half-life of both SSRIs [24] and antidepressants in general. Antidepressants with a lower half-life, such as paroxetine , duloxetine , and venlafaxine , have been implicated in higher incidences of withdrawal symptoms and more severe withdrawal ...

  9. Tesofensine - Wikipedia

    en.wikipedia.org/wiki/Tesofensine

    Tesofensine has a long half-life of about 9 days (220 h) [4] "and is mainly metabolized by cytochrome P4503A4 to its desalkyl metabolite M1" NS2360. [10] [11] NS2360 is the only metabolite detectable in human plasma. It has a longer half-life than tesofensine, i.e. approximately 16 days (374 h) in humans, and has an exposure of 31–34% of the ...

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