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[3] Rifampicin was discovered in 1965, marketed in Italy in 1968, and approved in the United States in 1971. [5] [6] [7] It is on the World Health Organization's List of Essential Medicines. [8] The World Health Organization classifies rifampicin as critically important for human medicine. [9] It is available as a generic medication. [3]
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
The hope of a fixed-dose combination pill is to increase the likelihood that people will take all of three medications. [5] Also, if people forget to take one or two of their drugs, they might not then develop resistance to the remaining drugs.
Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis. [1] It is a fixed dose combination of isoniazid and rifampicin (rifampin). [1] It is used together with other antituberculosis medication. [1] It is taken by mouth. [1] It is on the World Health Organization's List of Essential Medicines. [2]
Iron rings used in a laboratory. An iron ring or ring clamp is an item of laboratory equipment which comprises a conjoined metal ring and radially-extending rod. [1] In some cases, the rod terminates in a screw clamp for attachment to a retort stand or other support; in others, the rod may be attached to a stand by means of a laboratory clamp holder. [2]
Marman clamps are used extensively in spaceflight systems and are common mechanical load-transfer and clamping mechanisms for connecting the upper stage and the satellite payload of space vehicles, [3] [4] for example, on the Cassini Plasma Spectrometer on the Cassini orbiter. They may also be used to join stages of a booster rocket. [3]
Cramp-rings are rings anciently worn as a cure for cramp and "falling-sickness" or epilepsy. [1] The legend is that the first one was presented to Edward the Confessor by a pilgrim on his return from Jerusalem, its miraculous properties being explained to the king.
Sites of substitution in second-generation fluoroquinolone antibiotics: Here, and in following the orientation of the quinolones are flipped with respect to horizontal and vertical axes, relative to earlier images; the nitrogen (N)-containing pyridine ring is now on the left, and the N-1 atom and C-6 carbonyl are at 12 o'clock and 6 o'clock in ...