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A "Basic Status Code" SMTP reply consists of a three digit number (transmitted as three numeric characters) followed by some text. The number is for use by automata (e.g., email clients) to determine what state to enter next; the text ("Text Part") is for the human user. The first digit denotes whether the response is good, bad, or incomplete:
When you get a message from a "MAILER-DAEMON" or a "Mail Delivery Subsystem" with a subject similar to "Failed Delivery," this means that an email you sent was undeliverable and has been bounced back to you. These messages are sent automatically and often include the reason for the delivery failure.
User-level email clients typically use SMTP only for sending messages to a mail server for relaying, and typically submit outgoing email to the mail server on port 587 or 465 per RFC 8314. For retrieving messages, IMAP (which replaced the older POP3 ) is standard, but proprietary servers also often implement proprietary protocols, e.g ...