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Keratin 14 was the first type I keratin sequence determined. [5] Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene. [6] [7] [8] Keratin 14 is usually found as a heterodimer with type II keratin 5 and form the cytoskeleton of epithelial cells.
The term cytokeratin began to be used in the late 1970s, when the protein subunits of keratin intermediate filaments inside cells were first being identified and characterized. [2] In 2006 a new systematic nomenclature for mammalian keratins was created, and the proteins previously called cytokeratins are simply called keratins (human ...
- The right panel shows high magnification on a positive area, confirming adenocarcinoma, as it shows tumor cells with large nuclei and prominent nucleoli. AE1/AE3 is an antibody cocktail that is used in immunohistochemistry , being generally positive in the cytoplasm of carcinomas (cancers of epithelial origin).
34βE12, often written as 34betaE12 and also known as CK34βE12 and keratin 903 (CK903), is an antibody specific for high molecular weight cytokeratins 1, 5, 10 and 14. [ 1 ] [ 2 ] It is sometimes, less precisely, referred to as high-molecular weight keratin ( HMWK ) and high-molecular weight cytokeratin ( HMWCK ).
Membrane attack complex (Terminal complement complex C5b-9) A membrane attack complex attached to a pathogenic cell The membrane attack complex (MAC) or terminal complement complex (TCC) is a complex of proteins typically formed on the surface of pathogen cell membranes as a result of the activation of the host's complement system, and as such is an effector of the immune system.
Others lead to antibodies that the immune system only produces for a few weeks following resolution. After seroreversion, tests can no longer detect antibodies in a patient's serum. [14] The immune system generates antibodies to any antigen, so seroconversion can occur as a result of either natural infection or as a result of vaccination.
CD14 is expressed mainly by macrophages and (at 10-times lesser extent) by neutrophils.It is also expressed by dendritic cells.The soluble form of the receptor (sCD14) is secreted by the liver and monocytes and is sufficient in low concentrations to confer LPS-responsiveness to cells not expressing CD14. mCD14 and sCD14 are also present on enterocytes.
Type+I+Keratin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Proteopedia page on keratins This protein -related article is a stub .