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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed. [1]
The pharmacokinetics of phentermine are dose-dependent. [6] [6] Peak concentrations of phentermine are reached 6 hours following oral administration of a dose of 15 mg. [6] The steady-state levels of phentermine with continuous administration have been found to be around 200 ng/mL in clinical studies. [6]
amitriptyline – tricyclic antidepressant used to treat separation anxiety, excessive grooming dogs and cats; amlodipine – calcium channel blocker used to decrease blood pressure; amoxicillin – antibacterial; apomorphine – emetic (used to induce vomiting) artificial tears – lubricant eye drops used as a tear supplement
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
The lethal dose for 50% of dogs is 100 – 200 mg per kilogram (kg) of body weight, yet some dogs will exhibit signs of toxicosis after ingesting as little as 20 mg per kg. [38] In case of accidental intake of chocolate, especially involving a smaller dog, contact a veterinarian or animal poison control immediately; it is commonly recommended ...
Mephentermine is the generic name of the drug and its INN Tooltip International Nonproprietary Name, BAN Tooltip British Approved Name, and DCF Tooltip Dénomination Commune Française. [ 1 ] [ 2 ] [ 3 ] In the case of the sulfate salt , its USAN Tooltip United States Adopted Name is mephentermine sulfate and its BANM Tooltip British Approved ...
Fenfluramine is indicated for the treatment of seizures associated with Dravet syndrome and Lennox–Gastaut syndrome in people age two and older. [3] [7] [4]Dravet syndrome is a life-threatening, rare and chronic form of epilepsy. [7]
Science Diet was developed in the 1960s by Mark L. Morris Jr. (1934 – 2007). Morris was the son of veterinarian Dr. Mark Morris Sr., who pioneered the field of veterinary clinical nutrition when asked to create a specialized diet for the original seeing-eye dog, Buddy, a female German Shepherd with kidney disease.