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The cells targeted for the treatment of osteoarthritis are chondrocytes, synoviocytes, and their progenitors. Since the joint capsule is relatively well contained, intra-articular injections are highly successful at delivering the therapeutic gene therapy locally to the target cell types. Treatment of osteoarthritis may be successful via:
Weight loss and exercise are the most safe and effective long-term treatments, in contrast to short-term treatments which usually have risk of long-term harm. [ 69 ] High impact exercise can increase the risk of joint injury, whereas low or moderate impact exercise, such as walking or swimming, is safer for people with osteoarthritis. [ 68 ]
Several approved drugs are being investigated as repurposed agents in the treatment of osteoarthritis such as liraglutide (anti-diabetic and anti-obesity drug: NCT02905864), Metformin (anti-diabetic drug: NCT04767841, NCT05034029), Zoledronic acid (anti-osteoporotic drug: NCT04303026), etc. [4] Paroxetine has been deemed to have dmoad activity ...
Post-traumatic osteoarthritis is the most common variation of post-traumatic arthritis. [3] Between 20 and 50% [4] of all osteoarthritis cases are preceded by post-traumatic arthritis. Patients having post-traumatic osteoarthritis are usually younger than osteoarthritis patients without any previous physical injuries. [5]
Needle lavage should not be used in an attempt to treat persons seeking long-term relief for symptomatic osteoarthritis of the knee. [4] The use of this treatment in this case has not been shown to decrease pain, stiffness, tenderness, or swelling, or to increase 50-foot walking time or body function. [4]
Pain in the groin, called anterior hip pain, is most often the result of osteoarthritis, osteonecrosis, occult fracture, acute synovitis, and septic arthritis; pain on the sides of the hip, called lateral hip pain, is usually caused by bursitis; pain in the buttock, called posterior or gluteal hip pain, which is the least common type of hip ...
Arthroscopy is commonly used for treatment of diseases of the shoulder including subacromial impingement, acromioclavicular osteoarthritis, rotator cuff tears, frozen shoulder (adhesive capsulitis), chronic tendonitis, removal of loose bodies and partial tears of the long biceps tendon, SLAP lesions and shoulder instability. The most common ...
RSO, by targeting the inflamed synovium, aims to reduce the number and activity of macrophages, thereby relieving joint inflammation and slowing down osteoarthritis progression. [5] Long-term results have been observed in human knee [6] and finger osteoarthritis. [7]
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