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  2. Grapefruit–drug interactions - Wikipedia

    en.wikipedia.org/wiki/Grapefruit–drug_interactions

    Grapefruit–drug interactions that affect the pre-systemic metabolism (i.e., the metabolism that occurs before the drug enters the blood) of drugs have a different duration of action than interactions that work by other mechanisms, such as on absorption, discussed below.

  3. Grapefruit can interfere with your medications — here's what ...

    www.aol.com/lifestyle/grapefruit-interfere...

    That's why it's important to find out from your health care provider or a pharmacist if any of your medications interact with grapefruit. In addition, grapefruit can have the opposite effect on ...

  4. CYP3A4 - Wikipedia

    en.wikipedia.org/wiki/CYP3A4

    The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...

  5. Drug interaction - Wikipedia

    en.wikipedia.org/wiki/Drug_interaction

    In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs.

  6. Naringenin - Wikipedia

    en.wikipedia.org/wiki/Naringenin

    Naringenin is a flavanone from the flavonoid group of polyphenols. [2] It is commonly found in citrus fruits, especially as the predominant flavonone in grapefruit. [2]The fate and biological functions of naringenin in vivo are unknown, remaining under preliminary research, as of 2024. [2]

  7. Grapefruit can interfere with your medications — here's what ...

    www.aol.com/grapefruit-interfere-medications...

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  8. Fentanyl - Wikipedia

    en.wikipedia.org/wiki/Fentanyl

    Fentanyl contamination in cocaine, methamphetamine, ketamine, MDMA, and other drugs is common. [93] [94] A kilogram of heroin laced with fentanyl may sell for more than US$100,000, but the fentanyl itself may be produced far more cheaply, for about US$6,000 per kilogram. While Mexico and China are the primary source countries for fentanyl and ...

  9. Can I Have Grapefruit with Cialis? - AOL

    www.aol.com/grapefruit-cialis-115700221.html

    Unlike orange juice, grapefruit juice can impact how Cialis is metabolized in your body, leading to increased levels of the medication in your system. That can be dangerous for a variety of reasons.