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Toremifene, a chlorinated tamoxifen derivative developed to avoid hepatic carcinomas, was associated with fewer DNA adducts in the liver than tamoxifen in preclinical studies. It is used as endocrine therapy for women with estrogen or progesterone receptor-positive, stage 4 or recurrent metastatic breast cancer [7] and has demonstrated similar ...
Antiestrogens include selective estrogen receptor modulators (SERMs) like tamoxifen, clomifene, and raloxifene, the ER silent antagonist and selective estrogen receptor degrader (SERD) fulvestrant, [6] [7] aromatase inhibitors (AIs) like anastrozole, and antigonadotropins including androgens/anabolic steroids, progestogens, and GnRH analogues.
Oral exemestane 25 mg/day for 2–3 years of adjuvant therapy was generally more effective than 5 years of continuous adjuvant tamoxifen in the treatment of postmenopausal women with early-stage estrogen receptor-positive/unknown receptor status breast in a large well-designed [citation needed] trial. Preliminary data from the open-label TEAM ...
The FDA rule mandating women be notified of their breast density is the result of intense lobbying by women who found champions in state and federal legislators to get laws introduced and passed.
Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. [13] It is also being studied for other types of cancer. [13] It has been used for Albright syndrome. [14] Tamoxifen is typically taken daily by mouth for five years for breast cancer. [14]
This time, she says, it’s different. “This medication has given me my life back,” says Doty, who’s lost 118 lbs. since starting GLP-1 drug Mounjaro two years ago, when she was 279 lbs.
A 2024 review in The Lancet Diabetes & Endocrinology found that muscle loss is a major side effect from taking weight-loss medications like GLP-1s, which makes getting adequate protein in during ...
Tamoxifen is also thought to lower the risk of breast cancer in those who have a predisposition or at risk. [9] Tamoxifen may be used in pre and postmenopausal women. [10] Toremifene is a similar SERM drug to tamoxifen, but is less common and only approved for treatment of metastatic cancer. Toremifene is generally prescribed once tamoxifen is ...
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261