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Influenza viruses, particularly influenza A virus, evolve quickly, so flu vaccines are updated regularly to match which influenza strains are in circulation. Vaccines provide protection against influenza A virus subtypes H1N1 and H3N2 and one or two influenza B virus subtypes.
Influenza A virus (IAV) is the only species of the genus Alphainfluenzavirus of the virus family Orthomyxoviridae. [1] It is a pathogen with strains that infect birds and some mammals, as well as causing seasonal flu in humans. [2]
Mammalian influenza viruses tend to be labile, but can survive several hours in mucus. [57] Avian influenza virus can survive for 100 days in distilled water at room temperature, and 200 days at 17 °C (63 °F). The avian virus is inactivated more quickly in manure, but can survive for up to two weeks in feces on cages.
Three virus families, Influenza virus A, B, and C are the main infective agents that cause influenza. During periods of cooler temperature, influenza cases increase roughly tenfold or more. Despite the higher incidence of manifestations of the flu during the season, the viruses are actually transmitted throughout populations all year round.
Pigs can harbor influenza viruses adapted to humans and others that are adapted to birds, allowing the viruses to exchange genes and create a pandemic strain. A 2007 study reported: "In swine, three influenza A virus subtypes (H1N1, H3N2, and H1N2) are circulating throughout the world. In the United States, the classic H1N1 subtype was ...
The G4 virus, also known as the "G4 swine flu virus" (G4) and "G4 EA H1N1", is a swine influenza virus strain discovered in China. [68] The virus is a variant genotype 4 (G4) Eurasian avian-like (EA) H1N1 virus that mainly affects pigs, but there is some evidence of it infecting people. [68]
Influenza A virus subtype H5N1: 455 [235] 2004 Indonesia dengue epidemic 2004 Indonesia: Dengue fever: 658 [236] 2004 Sudan Ebola outbreak 2004 Sudan: Ebola: 7 [237] 2004–2005 Angola Marburg virus outbreak 2004–2005 Angola: Marburg virus: 227 [229] 2005 dengue outbreak in Singapore: 2005 Singapore: Dengue fever: 27 [238] 2006 Luanda cholera ...
Influenza ward at Walter Reed Hospital, in Washington, D.C., during the 1918 flu pandemic. An influenza pandemic is an epidemic of an influenza virus that spreads across a large region (either multiple continents or worldwide) and infects a large proportion of the population.