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Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. ... Bisphenol A's interacts with the estrogen-related receptor ...
Bisphenol A is an endocrine disruptor that can mimic estrogen and has been shown to cause negative health effects in animal studies. Bisphenol A closely mimics the structure and function of the hormone estradiol by binding to and activating the same estrogen receptor as the natural hormone.
There is evidence that bisphenol A functions as a xenoestrogen by binding strongly to ERR-γ. [8] BPA as well as its nitrated and chlorinated metabolites seems to binds strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER)., [8] [10] BPA binding to ERR-γ preserves its basal constitutive activity. [8]
BPA: Bisphenol A, or BPA, ... But like phthalates, it disrupts hormones and has been linked to higher risks of infertility, PCOS, diabetes, cardiovascular disease and breast and prostate cancer.
Xenoestrogens are a type of xenohormone that imitates estrogen.They can be either synthetic or natural chemical compounds.Synthetic xenoestrogens include some widely used industrial compounds, such as PCBs, BPA, and phthalates, which have estrogenic effects on a living organism even though they differ chemically from the estrogenic substances produced internally by the endocrine system of any ...
A comparison of the structures of the natural estrogen hormone estradiol (left) and one of the nonyl-phenols (right), a xenoestrogen endocrine disruptor. Endocrine disruptors, sometimes also referred to as hormonally active agents, [1] endocrine disrupting chemicals, [2] or endocrine disrupting compounds [3] are chemicals that can interfere with endocrine (or hormonal) systems. [4]
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) is a metabolite of bisphenol A (BPA). [1] MBP has potent estrogenic activity in vitro and in vivo , up to thousandfold stronger than BPA. [ 2 ] It may also play a role in neuronal cell apoptosis [ 3 ] and may increase risk for several forms of cancer.
The chemical structure of bisphenol A. Bisphenol A (BPA) is used in polycarbonate plastic consumer goods and aluminum can liners. [45] BPA is an example of an endocrine disruptor which negatively affects reproductive development by acting as an estrogen mimicker (xenoestrogen) and a likely androgen mimicker. [46]