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Younger individuals, if at high risk for dying from CLL, may consider allogeneic hematopoietic stem cell transplantation (HSCT). Myeloablative (bone marrow killing) forms of allogeneic stem cell transplantation, a high-risk treatment using blood cells from a healthy donor, may be curative, but treatment-related toxicity is significant. [80]
A B-cell leukemia is any of several types of lymphoid leukemia which affect B cells. [1] Types include (with ICD-O code): [citation needed] 9823/3 – B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma; 9826/3 – Acute lymphoblastic leukemia, mature B-cell type; 9833/3 – B-cell prolymphocytic leukemia
CD20. Approximately 95% of B-cell lymphomas express CD20, but CD20 is not critical for B-cell survival. Clonal B-cells spontaneously mutate the idiotypic region of their immunoglobulin. This high mutation rate makes them prone to the selection of B-cells lacking the CD20 antigen following treatment with CD20-targeting monoclonal antibodies.
The B symptoms, such as fever, night sweats, and weight loss, are often present as well. [19] Central nervous system (CNS) symptoms such as cranial neuropathies due to meningeal infiltration are identified in less than 10% of adults and less than 5% of children, particularly mature B-cell ALL (Burkitt leukemia) at presentation. [20]
T-cell prolymphocytic leukemia (T-PLL) is a very rare and aggressive leukemia affecting adults; somewhat more men than women are diagnosed with this disease. [24] Despite its overall rarity, it is the most common type of mature T cell leukemia; [ 25 ] nearly all other leukemias involve B cells .
Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white blood cells) are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma. ALL is the ...
Micrograph showing Hodgkin's lymphoma, a type of B cell lymphoma that is usually considered separate from other B cell lymphomas. Field stain. CT scan of primary B cell lymphoma in the left ilium, as diffuse cortical and trabecular thickening of the hemipelvis, mimicking Paget's disease. [2] There are numerous kinds of lymphomas involving B cells.
B-cell CLL/lymphoma refers to a family of genes associated with certain types of lymphoma and leukemia. Although named for B-cell chronic lymphocytic leukemia, they can be associated with other malignancies. Members include: CCND1 (also known as "BCL1") BCL2; BCL3; BCL5; BCL6, BCL6B; BCL7A, BCL7B, BCL7C; BCL8; BCL9; BCL10; BCL11A, BCL11B
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