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In survival analysis, the hazard ratio (HR) is the ratio of the hazard rates corresponding to the conditions characterised by two distinct levels of a treatment variable of interest. For example, in a clinical study of a drug, the treated population may die at twice the rate of the control population.
This interpretation of the baseline hazard as "hazard of a baseline subject" is imperfect, as the covariate being 0 is impossible in this application: a P/E of 0 is meaningless (it means the company's stock price is 0, i.e., they are "dead"). A more appropriate interpretation would be "the hazard when all variables are nil".
In survival analysis, hazard rate models are widely used to model duration data in a wide range of disciplines, from bio-statistics to economics. [1]Grouped duration data are widespread in many applications.
In full generality, the accelerated failure time model can be specified as [2] (|) = ()where denotes the joint effect of covariates, typically = ([+ +]). (Specifying the regression coefficients with a negative sign implies that high values of the covariates increase the survival time, but this is merely a sign convention; without a negative sign, they increase the hazard.)
The Nelson–Aalen estimator is a non-parametric estimator of the cumulative hazard rate function in case of censored data or incomplete data. [1] It is used in survival theory, reliability engineering and life insurance to estimate the cumulative number of expected events. An "event" can be the failure of a non-repairable component, the death ...
In two-sector macroeconomic models, the Harrod–Johnson diagram, occasionally referred to as the Samuelson-Harrod-Johnson diagram, is a way of visualizing the relationship between the output price ratios, the input price ratios, and the endowment ratio of the two goods. [1] [2] Often the goods are a consumption and investment good, and this ...
As usual for monotonic relationships, the likelihood ratio's monotonicity comes in handy in statistics, particularly when using maximum-likelihood estimation. Also, distribution families with MLR have a number of well-behaved stochastic properties, such as first-order stochastic dominance and increasing hazard ratios. Unfortunately, as is also ...
If the hazard ratio is , there are total subjects, is the probability a subject in either group will eventually have an event (so that is the expected number of events at the time of the analysis), and the proportion of subjects randomized to each group is 50%, then the logrank statistic is approximately normal with mean () and variance 1. [4]