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Cotinine has an in vivo half-life of approximately 20 hours, and is typically detectable for several days (up to one week) after the use of tobacco. The level of cotinine in the blood, saliva, and urine is proportionate to the amount of exposure to tobacco smoke, so it is a valuable indicator of tobacco smoke exposure, including secondary (passive) smoke. [14]
[31] [32] Other common side effects depend on the formulation of nicotine. [1] Common side effects with the gum include nausea, hiccups, and irritation of the mouth. [1] Common side effects with the patch include skin irritation and a dry mouth while the inhaler commonly results in a cough, runny nose, or headaches. [1]
Clonidine may reduce withdrawal symptoms and "approximately doubles abstinence rates when compared to a placebo," but its side effects include dry mouth and sedation, and abruptly stopping the drug can cause high blood pressure and other side effects. [46] [47] There is no good evidence anxiolytics are helpful. [48]
A new review of existing studies pinpoints the most effective strategies that can help a person quit smoking. These include a common anti-nicotine drug, a plant-based drug, and nicotine e-cigarettes.
Experts agree that a combination of pharmaceutical intervention (such as nicotine patches) and psychotherapy has been shown to be the most effective in quitting smoking. Therapy “can be very ...
Some drugs used for weight loss are only FDA-approved for improved blood sugar control in adults with type 2 diabetes. Two examples include metformin and Rybelsus® (semaglutide). Two examples ...
Varenicline is indicated for use as an aid to smoking cessation treatment [5] and for the treatment of the signs and symptoms of dry eye disease. [6] Varenicline is used to help people stop smoking tobacco (smoking cessation). A meta-analysis found that 20% of people treated with varenicline remain abstinent from smoking at one year. [15]
The effects of nicotine can be differentiated between short-term and long-term use. Short-term nicotine use, such as that associated with nicotine replacement therapy (NRT) for smoking cessation, appears to pose little cardiovascular risk, even for patients with known cardiovascular conditions. In contrast, longer-term nicotine use may not ...
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