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WGCNA can be used as a data reduction technique (related to oblique factor analysis), as a clustering method (fuzzy clustering), as a feature selection method (e.g. as gene screening method), as a framework for integrating complementary (genomic) data (based on weighted correlations between quantitative variables), and as a data exploratory ...
The concept of gene co-expression networks was first introduced by Butte and Kohane in 1999 as relevance networks. [6] They gathered the measurement data of medical laboratory tests (e.g. hemoglobin level ) for a number of patients and they calculated the Pearson correlation between the results for each pair of tests and the pairs of tests which showed a correlation higher than a certain level ...
The sample size is an important feature of any empirical study in which the goal is to make inferences about a population from a sample. In practice, the sample size used in a study is usually determined based on the cost, time, or convenience of collecting the data, and the need for it to offer sufficient statistical power .
Biweight midcorrelation has been implemented in the R statistical programming language as the function bicor as part of the WGCNA package [3] Also implemented in the Raku programming language as the function bi_cor_coef as part of the Statistics module.
In a random network the maximum degree, or the expected largest hub, scales as k max ~ log N, where N is the network size, a very slow dependence. In contrast, in scale-free networks the largest hub scales as k max ~ ∼N 1/(γ−1) indicating that the hubs increase polynomically with the size of the network.
It can be used in calculating the sample size for a future study. When measuring differences between proportions, Cohen's h can be used in conjunction with hypothesis testing . A " statistically significant " difference between two proportions is understood to mean that, given the data, it is likely that there is a difference in the population ...
Generally Bessel's correction is an approach to reduce the bias due to finite sample size. Such finite-sample bias correction is also needed for other estimates like skew and kurtosis, but in these the inaccuracies are often significantly larger. To fully remove such bias it is necessary to do a more complex multi-parameter estimation.
In statistics, asymptotic theory, or large sample theory, is a framework for assessing properties of estimators and statistical tests. Within this framework, it is often assumed that the sample size n may grow indefinitely; the properties of estimators and tests are then evaluated under the limit of n → ∞. In practice, a limit evaluation is ...