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Congenital insensitivity to pain (CIP), also known as congenital analgesia, is one or more extraordinarily rare conditions in which a person cannot feel (and has never felt) physical pain. [1] The conditions described here are separate from the HSAN group of disorders, which have more specific signs and cause.
Marsili syndrome is an extremely rare genetic disorder which is characterized by symptoms similar to those reported on individuals with congenital insensitivity to pain with anhidrosis. It can be fatal if it goes unnoticed/undiagnosed.
Since people with this condition are unable to sweat, they are unable to properly regulate their body temperature. [1] Those affected are unable to feel pain and temperature. [2] [3] The absence of pain experienced by people with CIPA puts them at high risk for accidental self-injury. Corneal ulceration occurs due to lack of protective impulses ...
The onset of the disease varies between the 2nd and 5th decade of life, [2] albeit congenital or childhood onset has occasionally been reported. [1] [9] With the progression of the disease, the affected individuals lose the ability to feel pain in their feet and legs. Minor injuries in the painless area can result in slow-healing wounds which ...
Hereditary sensory neuropathy type 1 is a condition characterized by nerve abnormalities in the legs and feet (peripheral neuropathy). Many people with this condition have tingling, weakness, and a reduced ability to feel pain and sense hot and cold.
This type of familial episodic pain syndrome is characterized by infancy-onset intense and debilitating upper-body episodic pain. It's caused by mutations in the TRPA1 gene, in chromosome 8 . It was first described in 2010 by Kremeyer et al. in 21 affected members from a large 4-generation Colombian family.
It’s an inflammatory disease with no cure that can cause the bones in the spine to fuse over time, according to the Mayo Clinic. Symptoms typically begin in early adulthood, with back pain ...
Amplified musculoskeletal pain is a syndrome which is a set of characteristic symptoms and signs. Essentially, the syndrome is characterized by diffuse, ongoing, daily pain associated with relatively high levels of incapability and greater care-seeking behavior.