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The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
In this latter group, statin assignment was not automatic, but was recommended to occur only after a clinician-patient risk discussion with shared decision making where other risk factors and lifestyle are addressed, the potential for benefit from a statin is weighed against the potential for adverse effects or drug interactions and informed ...
A new analysis re-evaluates statins and who should use them. Statins are widely used to help lower cholesterol. Using a new analysis, researchers found that millions of people may be taking ...
Comparable to statins and ezetimibe, fibrates are usually well-tolerated with mild adverse reactions, with the exception of gemfibrozil. Some of the more prevalent side effects are minor gastrointestinal disturbances such as abdominal pain and cholithiasis on account of the increased excretion of biliary cholesterol. [23]
“But, if somebody absolutely cannot tolerate statins. this would be one of the other medications we can turn to as an alternative. It may not have as much benefit, but is a good alternative.” ...
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In those at intermediate risk or low risk, the use of statin therapy depends on individual patient factors such as age, cholesterol levels, and risk factors. [4] Statins are considered the first-line agents but other drugs can be substituted if the lipid targets are not achieved with statin therapy or if they are not tolerated. [4] [14] [15]
His cholesterol levels exceeded 1,000 mg per deciliter, far higher than his baseline level, between 210 and 300 mg. Normal cholesterol ranges for adults are below 200 mg, five times lower than ...
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