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Variants of severe acute respiratory syndrome coronavirus 2 are viruses that, while similar to the original, have genetic changes that are of enough significance to lead virologists to label them separately. SARS-CoV-2 is the virus that causes coronavirus disease 2019 (COVID-19).
Analysis of samples from Maharashtra had revealed that compared to December 2020, there was an increase in the fraction of samples with the E484Q and L452R mutations. [2] Lineage B.1.617 later came to be dubbed a double mutant by news media. [3] Lineage B.1.617 has three sublineages according to the PANGO nomenclature:
Iota variant, [1] also known as lineage B.1.526, is one of the variants of SARS-CoV-2, the virus that causes COVID-19. It was first detected in New York City in November 2020. The variant has appeared with two notable mutations: the E484K spike mutation, which may help the virus evade antibodies, and the S477N mutation, which helps the virus ...
SARS-CoV-2 is the seventh known coronavirus to infect people, after 229E, NL63, OC43, HKU1, MERS-CoV, and the original SARS-CoV. [105] Like the SARS-related coronavirus implicated in the 2003 SARS outbreak, SARS‑CoV‑2 is a member of the subgenus Sarbecovirus (beta-CoV lineage B). [106] [107] Coronaviruses undergo frequent recombination. [108]
On February 18, 2021, the Department of Health of the Philippines confirmed the detection of two mutations of COVID-19 in Central Visayas after samples from patients were sent to undergo genome sequencing. The mutations were later named as E484K and N501Y, which were detected in 37 out of 50 samples, with both mutations co-occurrent in 29 out ...
A new COVID-19 subvariant, known as XBB.1.16 but often called "Arcturus," has progressively become more viral here in the United States, accounting for 10% of infections through late April.
The variant has five defining mutations (I4205V and D1183Y in the ORF1ab gene, and S13I, W152C, L452R in the spike protein's S-gene), [2] of which the L452R (previously also detected in other unrelated lineages) was of particular concern. [3]
The European Centre for Disease Prevention and Control (ECDC) also list a fourth spike mutation of interest: [14] D614G. This is a substitution at position 614, an aspartic acid-to-glycine substitution. [15] Other variants which have the D614G mutation include the Beta and Delta variants, and the mutation is associated with increased ...