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  2. Area under the curve (pharmacokinetics) - Wikipedia

    en.wikipedia.org/wiki/Area_under_the_curve...

    In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance ...

  3. Ceftriaxone - Wikipedia

    en.wikipedia.org/wiki/Ceftriaxone

    Ceftriaxone, sold under the brand name Rocephin, is a third-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [4] These include middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease. [4]

  4. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    In such cases, the effective dose is the amount and frequency that produces the desired effect, which can vary, and can be greater or less than the therapeutically effective dose. The Certain Safety Factor, also referred to as the Margin of Safety (MOS), is the ratio of the lethal dose to 1% of population to the effective dose to 99% of the ...

  5. Dose-ranging study - Wikipedia

    en.wikipedia.org/wiki/Dose-ranging_study

    The main goal of a dose-ranging study is to estimate the response vs. dose given, so as to analyze the efficacy and safety of the drug. Although such a response will nevertheless be available from phase III or phase IV trials, it is important to carry out dose-ranging studies in the earlier phase I or phase II stages. There are advantages to ...

  6. Taking This Daily Vitamin Could Slash Dementia Risk By 40 ...

    www.aol.com/taking-daily-vitamin-could-slash...

    $20.99 at Amazon. Orange Vitamin D3. Rated at 4.7 stars by over 6,000 happy customers on Amazon, this daily vitamin is a tried-and-true product that's affordable and even offers a refreshing ...

  7. Cephalosporin - Wikipedia

    en.wikipedia.org/wiki/Cephalosporin

    Since August 2012, the third-generation cephalosporin, ceftriaxone, is the only recommended treatment for gonorrhea in the United States (in addition to azithromycin or doxycycline for concurrent Chlamydia treatment). Cefixime is no longer recommended as a first-line treatment due to evidence of decreasing susceptibility. [30] Ceftriaxone ...

  8. Suspect in CEO’s killing hires high-profile attorney as ...

    www.aol.com/suspect-ceo-killing-hires-high...

    Luigi Mangione, accused of killing UnitedHealthcare’s CEO in Manhattan, has retained a high-profile New York attorney – a development revealed on the same day an official indicated the ...

  9. Defense secretary nominee Pete Hegseth's confirmation hearing ...

    www.aol.com/defense-secretary-nominee-pete...

    Watch Pete Hegseth's confirmation hearing. The hearing is expected to begin Tuesday at 9:30 a.m. ET, according to the Armed Services Committee website, which says it will have a live video.