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The fungal protein ERG2, a C-8 sterol isomerase, falls into the same protein family as sigma-1. Both localize to the ER membrane, although sigma-1 is also reported to be a cell surface receptor. Sigma-2 is an EXPERA domain protein [4] with a mostly intracellular (ER membrane) localization. [5]
The σ 1 receptor is defined by its unique pharmacological profile. In 1976 Martin reported that the effects of N-allylnormetazocine (SKF-10,047) could not be due to activity at the μ and κ receptors (named from the first letter of their selective ligands morphine and ketazocine, respectively) and a new type of opioid receptor was proposed; σ (from the first letter of SKF-10,047). [13]
Methylphenylpiracetam is a derivative of piracetam and a positive allosteric modulator of the sigma-1 receptor. [1] [2] [3] It differs from phenylpiracetam by having a methyl group. [2] E1R is the (4R,5S) stereoisomer of methylphenylpiracetam that has been shown to have the greatest effect on the modulation of the sigma-1 receptor. [2]
27346 69071 Ensembl ENSG00000109084 ENSMUSG00000037278 UniProt Q5BJF2 Q8VD00 RefSeq (mRNA) NM_014573 NM_133706 RefSeq (protein) NP_055388 NP_598467 Location (UCSC) Chr 17: 28.32 – 28.33 Mb Chr 11: 78.43 – 78.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The sigma-2 receptor (σ 2 R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases ...
Ligands of the sigma receptor. Subcategories. This category has the following 2 subcategories, out of 2 total. S. Sigma agonists (59 P) Sigma antagonists (13 P)
Agonists of the sigma receptors. Pages in category "Sigma agonists" The following 59 pages are in this category, out of 59 total.
This list may not reflect recent changes. ... Sigma receptor; Signal recognition particle receptor; Signaling peptide receptor; Signalling lymphocyte activation ...
Sigma receptors are defined by the presence of one amine binding site and three hydrophobic binding sites nearby in the ligand-binding region. [4] Thus, the N(b) atom in the central piperazine ring serves to interact with the amine binding site and the two phenethyl groups serve to fill two out of the three hydrophobic pockets.