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Hypersalivation can contribute to drooling if there is an inability to keep the mouth closed or difficulty in swallowing (dysphagia) the excess saliva, which can lead to excessive spitting. Hypersalivation also often precedes emesis (vomiting), where it accompanies nausea (a feeling of needing to vomit).
Cholinergic crisis, sometimes known by the mnemonic "SLUDGE syndrome" (salivation, lacrimation, urination, defecation, gastrointestinal distress, and emesis), [4] can be a consequence of: Contamination with – or excessive exposure to – certain chemicals including: nerve agents, (e.g., sarin, VX, Novichok agents).
When there is expression of muscarinic overstimulation due to excess acetylcholine at muscarinic acetylcholine receptors symptoms of visual disturbances, tightness in chest, wheezing due to bronchoconstriction, increased bronchial secretions, increased salivation, lacrimation, sweating, peristalsis, and urination can occur. [8] [9]
Less common symptoms include pain with swallowing/sore throat, increased salivation (also known as water brash), nausea, [17] chest pain, coughing, and globus sensation. [18] The acid reflux can induce asthma attack symptoms like shortness of breath, cough, and wheezing in those with underlying asthma. [18] GERD sometimes causes injury to the ...
Standard treatment for nerve agent poisoning is a combination of an anticholinergic to manage the symptoms, and an oxime as an antidote. [12] Anticholinergics treat the symptoms by reducing the effects of acetylcholine, while oximes displaces phosphate molecules from the active site of the cholinesterase enzymes, allowing the breakdown of ...
Drooling, or slobbering, is the flow of saliva outside the mouth. Drooling can be caused by excess production of saliva , inability to retain saliva within the mouth (incontinence of saliva), or problems with swallowing ( dysphagia or odynophagia ).
Also, sialorrhea (excessive salivation) may be remedied by a parotidectomy, yet treatment by medication or even duct ligation (surgical tying) are the less invasive approaches. [ 1 ] Treatment/Procedure
It is used to treat muscarinic symptoms but does not reverse AChE inhibition. It can counteract the excessive cholinergic activity caused by dichlofenthion poisoning by blocking muscarinic receptors. Atropine administration helps alleviate symptoms such as excessive salivation, bronchoconstriction, and bradycardia.