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Dormant, small, only one layer of flat granulosa cells: Primordial follicles are about 0.03–0.05 mm in diameter. Primary: Mitotic cells, cuboidal granulosa cells: Almost 0.1 mm in diameter Secondary: Presence of theca cells, multiple layers of granulosa cells: The follicle is now 0.2 mm in diameter Early tertiary
Sawyer et al. hypothesized that in sheep most of the granulosa cells develop from cells of the mesothelium (i.e., epithelial cells from the presumptive surface epithelium of the ovary). [5] In 2013, it was proposed that both granulosa cells and the ovarian surface epithelial cells are instead derived from a precursor cell called gonadal-ridge ...
Ovarian follicle activation can be defined as primordial follicles in the ovary moving from a quiescent (inactive) to a growing phase. The primordial follicle in the ovary is what makes up the “pool” of follicles that will be induced to enter growth and developmental changes that change them into pre-ovulatory follicles, ready to be released during ovulation.
The primary follicle takes four months to become a preantral, two months to become antral, and then passes to a mature (Graaf) follicle. The primary follicle has oocyte-lining cells that go from floor to cubic and begin to proliferate, increasing the metabolic activity of the oocyte and follicular cells, which release glycoproteins and ...
The rise in FSH levels recruits five to seven tertiary-stage ovarian follicles (this stage follicle is also known as a Graafian follicle or antral follicle) for entry into the menstrual cycle. These follicles, that have been growing for the better part of a year in a process known as folliculogenesis, compete with each other for dominance. [5]
An antral or secondary follicle, also known as Graafian follicle and tertiary follicle, is an ovarian follicle during a certain latter stage of folliculogenesis. Definitions differ in where the shift into an antral follicle occurs in the staging of folliculogenesis, with some stating that it occurs when entering the secondary stage, [ 1 ] and ...
Theca cells are a group of endocrine cells in the ovary made up of connective tissue surrounding the follicle. They have many diverse functions, including promoting folliculogenesis and recruitment of a single follicle during ovulation. [2] Theca cells and granulosa cells together form the stroma of the ovary.
The immature ova originate from cells from the dorsal endoderm of the yolk sac. Once they have reached the gonadal ridge they are called oogonia. Development proceeds and the oogonia become fully surrounded by a layer of connective tissue cells (pre-granulosa cells). In this way, the rudiments of the ovarian follicles are formed.