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Functional genomics is a field of molecular biology that attempts to describe gene (and protein) functions and interactions. Functional genomics make use of the vast data generated by genomic and transcriptomic projects (such as genome sequencing projects and RNA sequencing ).
Functional genomics: In functional genomics research, sequence alignment visualization is employed to study gene expression, regulatory elements, and protein-protein interactions. By visualizing sequence alignments in the context of functional annotations and gene networks, researchers can elucidate the biological functions and regulatory ...
However, there are relatively few databases dedicated to image collection, although some projects such as iNaturalist collect photos as a main part of their data. A special case of "images" are 3-dimensional images such as protein structures or 3D-reconstructions of anatomical structures. Image databases include, among others: [22] Allen Brain ...
Functional genomics attempts to answer questions about the function of DNA at the levels of genes, RNA transcripts, and protein products. A key characteristic of functional genomics studies is their genome-wide approach to these questions, generally involving high-throughput methods rather than a more traditional "gene-by-gene" approach.
Functional annotation can be performed through probabilistic methods. The distribution of hydrophilic and hydrophobic amino acids indicates whether a protein is located in a solution or membrane. Specific sequence motifs provide information on posttranslational modifications and final location of any given protein. [ 19 ]
This systematic approach to studying epistasis on a genome wide scale has significant implications for functional genomics. By identifying the negative and positive interactions between an unknown gene and a set genes within a known pathway, these methods can elucidate the function of previously uncharacterized genes within the context of a ...
For functional genomics, metabolomics can be an excellent tool for determining the phenotype caused by a genetic manipulation, such as gene deletion or insertion. Sometimes this can be a sufficient goal in itself—for instance, to detect any phenotypic changes in a genetically modified plant intended for human or animal consumption.
A genomic library is a collection of overlapping DNA fragments that together make up the total genomic DNA of a single organism.The DNA is stored in a population of identical vectors, each containing a different insert of DNA.