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Pituitary pars intermedia dysfunction (PPID), or equine Cushing's disease, is an endocrine disease affecting the pituitary gland of horses. It is most commonly seen in older animals, [ 1 ] and is classically associated with the formation of a long, wavy coat ( hirsutism ) and chronic laminitis .
A basal central:peripheral ratio of over 2:1, or a ratio over 3:1 when CRH is administered, is indicative of Cushing's disease. [8] This test has been the gold standard for distinguishing between Cushing's disease and ectopic corticotropin syndrome, [ 8 ] with a sensitivity and specificity of 94% for Cushing's disease, [ 11 ] and a very low ...
Horses are best managed by only allowing short grazing periods—less than 1 hour since they can rapidly ingest grass, [18] or confining them to a limited turn-out area or by use of a grazing muzzle. Horses with severe IR, that have recurrent laminitis, are not recommended to return to pasture. Hay low in NSC is provided in place of pasture.
Treatment of Cushing's depends on the cause. It is possible to cure Cushing's if the tumour is small, benign, and located on the adrenal gland; however, this is not common. [2] [6] Hypophysectomy is an option for patients with good clinical signs and a high life expectancy. Inoperable pituitary tumours may be treated with radiation, this is ...
Others include a practice called gingering alleged to make a horse appear more energetic, but any behavioral changes are generally a result of discomfort caused by the treatment. Sometimes natural remedies are all that is available, particularly in the global south or other isolated remote areas.
Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. [11] [7] [1] [12] It is a mixture of the sodium salts of estrogen conjugates found in horses, such as estrone sulfate and ...
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