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C. Garrison Fathman is a Professor of Medicine and Division Chief of Immunology and Rheumatology at Stanford University School of Medicine.He is also the Associate Director of the Institute for Immunity, Transplantation and Infection and Director of the Center for Clinical Immunology at Stanford University.
As of 2024, she is an emeritus professor at Scripps Research, and serves on the advisory boards of the La Jolla Institute for Immunology and the San Diego Biomedical Research Institute. [3] [4] Her research has focused on immune tolerance and autoimmunity, particularly type 1 diabetes, as well as the immune response to tumors.
Immune tolerance encompasses the range of physiological mechanisms by which the body reduces or eliminates an immune response to particular agents. It is used to describe the phenomenon underlying discrimination of self from non-self, suppressing allergic responses, allowing chronic infection instead of rejection and elimination, and preventing ...
Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system.Immunotherapy is designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies.
Immune tolerance is maintained by central and peripheral tolerance. During central tolerance, T-cells are selected in the thymus and allowed to enter the periphery based on the ability of the T-cell to recognize self-peptides (via its TCR) being presented in the context of self-MHC. If the TCR binds the peptide-MHC complex with high affinity ...
Immunosuppression is a reduction of the activation or efficacy of the immune system.Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.
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A review by the Memorial Sloan Kettering Cancer Center found no evidence that the Hoxsey Therapy was effective as a treatment for cancer. [48] Issels treatment – a regime recommended to be used alongside conventional treatment. It requires removal of metal fillings from the patient's mouth, and adherence to a restrictive diet.