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A brain tissue with Lewy bodies. The first major proposed cause of neuronal death in Parkinson's disease is the bundling, or oligomerization, of proteins.The protein alpha-synuclein has increased presence in the brains of Parkinson's Disease patients and, as α-synuclein is insoluble, it aggregates to form Lewy bodies (shown to left) in neurons.
A significant number of autosomal-dominant Parkinson's disease cases are associated with mutations in the LRRK2 gene [23] Mutations in LRRK2 are the most common known cause of familial and sporadic PD, accounting for approximately 5% of individuals with a family history of the disease and 3% of sporadic cases.
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor and non-motor systems. Symptoms typically develop gradually, with non-motor issues becoming more prevalent as the disease progresses.
Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. [ 1 ] [ 2 ] Parkinsonism gait problems can lead to falls and serious physical injuries.
Parkinson's Disease causes constipation and gastric dysmotility that is severe enough to endanger comfort and even health. [26] A factor in this is the appearance of Lewy bodies and Lewy neurites even before these affect the functioning of the substantia nigra in the neurons in the enteric nervous system that control gut functions. [27]
Parkinson-plus syndrome; Parkinson's disease; Parkinson's Disease (journal) Parkinson's disease and gut-brain axis; Research in Parkinson's disease; Parkinsonian gait; Parkinsonism; Pathophysiology of Parkinson's disease; PD-0298029; Prasinezumab
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