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X reactivation: in female patients heterozygous for the CDKL5 mutation, each cell expressing the mutant protein also carries a fully functional, but silent, CDKL5 gene copy on the inactivated X chromosome. One strategy for treatment of girls with CDD is thus to re-activate the silent, inactivated CDKL5 gene on the inactivated X chromosome.
CDKL5 is a gene that provides instructions for making a protein called cyclin-dependent kinase-like 5 ... Anticonvulsants were the mainstay of treatment for most ...
Ganaxolone, sold under the brand name Ztalmy, is a medication used to treat seizures in people with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder. [1] [3] Ganaxolone is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor positive modulator.
Soticlestat (TAK-935, OV-935) is an experimental anticonvulsant and cholesterol 24-hydroxylase inhibitor being investigated as a treatment for Dravet syndrome, Lennox–Gastaut syndrome, tuberous sclerosis complex, dup15q syndrome, and CDKL5 deficiency disorder.
The morphine treatment continued even after the patient showed signs of having a toxic reaction to it — even seizures, prosecutors claim. Vitas then elevated the patient to its crisis care service to deal with the reaction it had caused, according to the lawsuit, at a cost of four times the standard rate.
An FDA-approved medication already used to treat people who have type 2 diabetes and chronic kidney disease may also help lower their stroke and heart attack risk, a new study has found.
Rett syndrome (RTT) is a genetic disorder that typically becomes apparent after 6-18 months of age and almost exclusively in girls. [4] Symptoms include impairments in language and coordination, and repetitive movements. [4]
to order in one experimental treatment. Thus, the avoidance of small immediate costs – the cost of the extra effort required to order a less healthy meal – weighs in favor of healthy selections. The second bias, well documented in the Behavioral Economics literature, is the tendency