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The formulations may differ in terms of pharmacokinetic properties, particularly bioavailability; some must be taken with meals, whereas others may be taken without regard to food. [30] The choline salt of fenofibrate is available in the United States, sold as Trilipix, and may be taken without regard to meals. [24] [31]
The most common side effects are abdominal distension (bloating), abdominal pain (stomach ache), constipation, diarrhea, dry mouth, dyspepsia (heartburn), eructation (belching), flatulence (gas), nausea (feeling sick), abdominal discomfort, vomiting and raised blood levels of liver enzymes.
In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to kidney failure. The less lipophilic statins are less prone to cause this reaction, and are probably safer to be combined with fibrates than the more lipophilic statins are. Drug toxicity includes acute ...
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The FDA Adverse Event Reporting System (FAERS or AERS) is a computerized information database designed to support the U.S. Food and Drug Administration's (FDA) postmarketing safety surveillance program for all approved drug and therapeutic biologic products.
Common side effects include headache, dizziness, feeling tired, and intestinal upset. [3] Serious side effects may include angioedema, gallstones, liver problems, and muscle breakdown. [3] Use in pregnancy and breastfeeding is of unclear safety. [5] It belongs to the fibrates group of medications and works by decreasing the breakdown of lipids ...
In another study, a dietary supplement consisting of both soluble fibre (guar gum, pectin) and insoluble fibre (soy fibre, pea fibre, corn bran) was found to reduce LDL-cholesterol for individuals that have mild to moderate hypercholesterolaemia without reducing HDL-cholesterol or increasing triglycerides.
Most drugs and procedures have a multitude of reported adverse side effects; the information leaflets provided with virtually all drugs list possible side effects. Beneficial side effects are less common; some examples, in many cases of side-effects that ultimately gained regulatory approval as intended effects, are: