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Damage to skeletal muscle may take various forms. Crush and other physical injuries cause damage to muscle cells directly or interfere with blood supply, while non-physical causes interfere with muscle cell metabolism. When damaged, muscle tissue rapidly fills with fluid from the bloodstream, including sodium ions.
Failure of kidneys to remove excess fluid may cause: Swelling of the hands, legs, ankles, feet, or face; Shortness of breath due to extra fluid on the lungs (may also be caused by anemia) Polycystic kidney disease, which causes large, fluid-filled cysts on the kidneys and sometimes the liver, can cause: Pain in the back or side
A Danish study measured the median renal length to be 11.2 cm (4 + 7 ⁄ 16 in) on the left side and 10.9 cm (4 + 5 ⁄ 16 in) on the right side in adults. Median renal volumes were 146 cm 3 ( 8 + 15 ⁄ 16 cu in) on the left and 134 cm 3 ( 8 + 3 ⁄ 16 cu in) on the right.
The first symptoms of kidney failure are silent. Failing kidneys can’t remove extra fluid from the body, nor can they filter molecules like urea, which can be toxic in high dosages, from the blood.
Crush injury is compression of the arms, legs, or other parts of the body that causes muscle swelling and/or neurological disturbances in the affected areas of the body, while crush syndrome is a localized crush injury with systemic manifestations. [1]
Causes of edema that are generalized to the whole body can cause edema in multiple organs and peripherally. For example, severe heart failure can cause pulmonary edema, pleural effusions, ascites and peripheral edema. Such severe systemic edema is called anasarca. In rare cases, a parvovirus B19 infection may cause generalized edemas. [9]
Fluid may be also sent for gram stain, acid fast stain, or culture if high suspicion of infectious cause. [1] Bloody fluids may also be evaluated for malignant cells. [13] Fluid analysis may result in: transudative effusion: due to non-inflammatory causes (congestive heart failure, myxoedema, nephrotic syndrome)
Kidney ischemia [1] is a disease with a high morbidity and mortality rate. [2] Blood vessels shrink and undergo apoptosis which results in poor blood flow in the kidneys. More complications happen when failure of the kidney functions result in toxicity in various parts of the body which may cause septic shock, hypovolemia, and a need for surgery. [3]