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Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme. [1]Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties.
Non-stoichiometric compounds are chemical compounds, almost always solid inorganic compounds, having elemental composition whose proportions cannot be represented by a ratio of small natural numbers (i.e. an empirical formula); most often, in such materials, some small percentage of atoms are missing or too many atoms are packed into an ...
Guy also formulated a second strong law of small numbers: When two numbers look equal, it ain't necessarily so! [3] Guy explains this latter law by the way of examples: he cites numerous sequences for which observing the first few members may lead to a wrong guess about the generating formula or law for the sequence.
Contact resistance values are typically small (in the microohm to milliohm range). Contact resistance can cause significant voltage drops and heating in circuits with high current. Because contact resistance adds to the intrinsic resistance of the conductors, it can cause significant measurement errors when exact resistance values are needed.
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RD-1333 lead azide (MIL-DTL-46225), a version of lead azide with sodium carboxymethyl cellulose as a precipitating agent, was developed to meet that need. The Vietnam War saw an accelerated need for lead azide and it was during this time that Special Purpose Lead Azide (MIL-L-14758) was developed; the US government also began stockpiling lead ...
The basic Gurney equations for flat sheets assume that the sheet of material is a large diameter. Small explosive charges, where the explosive's diameter is not significantly larger than its thickness, have reduced effectiveness as gas and energy are lost to the sides. [1]
In linear algebra, Cramer's rule is an explicit formula for the solution of a system of linear equations with as many equations as unknowns, valid whenever the system has a unique solution. It expresses the solution in terms of the determinants of the (square) coefficient matrix and of matrices obtained from it by replacing one column by the ...