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Low doses of amitriptyline moderately improve sleep disturbances and reduce pain and fatigue associated with fibromyalgia. [33] It is recommended for fibromyalgia accompanied by depression by Association of the Scientific Medical Societies in Germany [ 33 ] and as a second-line option for fibromyalgia, with exercise being the first line option ...
Ramelteon, sold under the brand name Rozerem among others, is a melatonin agonist medication which is used in the treatment of insomnia. [3] [5] It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset. [3]
Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
Amitriptylinoxide (brand names Amioxid, Ambivalon, Equilibrin), or amitriptyline N-oxide, is a tricyclic antidepressant (TCA) which was introduced in Europe in the 1970s for the treatment of depression. [1] Amitriptylinoxide is both an analogue and metabolite of amitriptyline, and has similar effects as well as equivalent efficacy as an ...
Zolpidem tartrate, a common but potent sedative–hypnotic drug.Used for severe insomnia. Hypnotic (from Greek Hypnos, sleep [1]), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep [2] (or surgical anesthesia [note 1]) and to treat insomnia (sleeplessness).
Previous systematic reviews and meta-analyses had not comprehensively assessed TCAs in the same fashion, with the largest including only two TCAs (amitriptyline and clomipramine) and only 36 trials. [11] [12] A total of 103 short-term clinical trials with 10,590 participants employing 12 different TCAs (and TeCAs) were included. [11]
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Sleep Medicine Reviews is a bimonthly peer-reviewed medical journal covering research on the diagnosis and therapy of sleep disturbances and disorders (sleep medicine). It was established in 1997 and is published by Elsevier. The editors-in-chief are J. Krieger (Louis Pasteur University) and Michael V Vitiello (University of Washington).
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