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Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t 1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
The program launched on March 1, 2006, at the beginning of the annual meeting of the American Academy of Dermatology. [4] [6] [7] According to a study published in 2011, the program has not significantly reduced exposure of pregnant people to the drug in comparison to the previous SMART program. [8]
Pregnancy is an absolute contraindication as with most other vitamin A products, it should also be avoided when it comes to systemic use in any women that is of childbearing potential and not taking precautions to prevent pregnancy. [1] Toctino (the oral capsule formulation of alitretinoin) contains soya oil and sorbitol.
Breast development throughout pregnancy may result in significant Areola and Areolar gland enlargement, erectile nipples, and/or nipple sensitivity. [8] [9] A woman's breasts grow during pregnancy, typically 1 to 2 cup sizes. [10] A woman who wore a C cup bra prior to her pregnancy may need to buy an F cup or larger bra while nursing. [11]
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, [ 2 ] so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy.
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The new study found that women who had higher levels of fluoride during pregnancy reported later that their kids were more likely to have temper tantrums, complain of vague headaches and ...
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