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The reversal potential of the GABA B-mediated IPSP (inhibitory postsynaptic potential) is −100 mV, which is much more hyperpolarized than the GABA A IPSP. GABA B receptors are found in the central nervous system and the autonomic division of the peripheral nervous system. [2]
An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential. [1] The opposite of an inhibitory postsynaptic potential is an excitatory postsynaptic potential (EPSP), which is a synaptic potential that makes a postsynaptic neuron more likely to generate an action potential.
By contrast, IPSPs are induced by the binding of GABA(gamma-aminobutyric acid), or glycine. [4] Synaptic potentials are small and many are needed to add up to reach the threshold. This means a single EPSP/IPSP is typically not enough to trigger an action potential.
Gamma-aminobutyric acid. The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system.
The reversal potential of the GABA A-mediated inhibitory postsynaptic potential (IPSP) in normal solution is −70 mV, contrasting the GABA B IPSP (−100 mV). The active site of the GABA A receptor is the binding site for GABA and several drugs such as muscimol, gaboxadol, and bicuculline. [6]
Presynaptic inhibition occurs when an inhibitory neurotransmitter, like GABA, acts on GABA receptors on the axon terminal. Or when endocannabinoids act as retrograde messengers by binding to presynaptic CB1 receptors , thereby indirectly modulating GABA and the excitability of dopamine neurons by reducing it and other presynaptic released ...
On the other hand, if the reversal potential of the receptor to which the neurotransmitter binds is lower than the threshold potential, an inhibitory postsynaptic potential will occur (IPSP). [ 4 ]
The GABA B receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor and its mechanism of action differs significantly from the ionotropic receptors. Functionally, in mature organisms, activation of these receptors typically results in neural inhibition, primarily via the influx of chloride ions , although exceptions to ...