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Extravillous trophoblasts (EVTs), are one form of differentiated trophoblast cells of the placenta.They are invasive mesenchymal cells which function to establish critical tissue connection in the developing placental-uterine interface.
High grade chronic villitis has more than 10 inflamed villi per focus. High grade chronic villitis is differentiated into diffuse and patchy. The term patchy is used if less than 30% of distal villi are involved. The term diffuse is used if more than 30% of distal villi are involved. [citation needed] VUE has 2 prominent distinct patterns.
Hypoplasia (from Ancient Greek ὑπo-(hypo-) 'under' and πλάσις (plasis) 'formation'; adjective form hypoplastic) is underdevelopment or incomplete development of a tissue or organ. [1] Although the term is not always used precisely, it properly refers to an inadequate or below-normal number of cells. [ 2 ]
Villous intermediate trophoblast [1] polyhedral and uniform nuclei; prominent cell border; abundant eosinophilic to clear cytoplasm; cohesive growth; Implantation site intermediate trophoblast [1] pleomorphic irregular nuclei, large and hyperchromatic, may show multinucleation; abundant eosinophilic to amphophilic cytoplasm
Al-Gazali-Donnai-Mueller syndrome, also known as Hirschsprung's disease, hypoplastic nails, and minor dysmorphic features syndrome [1] is a rare and deadly genetic disorder which is characterized by Hirschsprung's disease, nail and distal limb hypoplasia, flat facies, upslanting palpebral fissures, narrow philtrum, high palate, micrognathia and low-set ears.
Post mortum showed a thin and dilated intestine with flat small bowel mucosa. A number of jejunal biopsies had been taken during life and these showed partial villous atrophy with by crypt hyperplasia and an increased number of mitotic figures in the crypts. Normal numbers and types of mononuclear cells were present in the lamina propria.
It includes clubbed feet, pulmonary hypoplasia and cranial anomalies related to the oligohydramnios. [clarification needed] Oligohydramnios is the decrease in amniotic fluid volume sufficient to cause deformations in morphogenesis of the baby. Oligohydramnios is the cause of Potter sequence, but there are many things that can lead to ...
The diagnosis is based on tissue examination, e.g. biopsy. The name of the lesion describes it microscopic appearance. It has nipple-like structures with fibrovascular cores that are long in relation to their width (villus-like), which are covered with a glandular pseudostratified columnar epithelium.