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The risk of developing prostate cancer increases with age; the average age of diagnosis is 67. Those with a family history of any cancer are more likely to have prostate cancer, particularly those who inherit cancer-associated variants of the BRCA2 gene.
Risk factors for prostate cancer include certain ethnicities, age and, in some cases, inherited genetic factors. So a family history may increase risk, but because this is such a common condition ...
Lowering the recommended age for baseline PSA testing in Black men could reduce prostate cancer deaths by about 30% without significantly increasing overdiagnosis rates, according to recent findings.
For men at a higher risk for prostate cancer, screening is recommended between ages 40 and 45. Those groups include Black men, people with a family history of the cancer, and those with a genetic ...
The Prostate Cancer Intervention versus Observation Trial (PIVOT) randomized 731 men diagnosed with localized prostate cancer to radical prostatectomy or observation (mean age 67 years; median PSA 7.8 ng/ml). [10] In the observation group, bone metastases and prostate cancer death occurred in 10.6% and 8.4%, respectively through 12 years. [10]
Ch8 The risk is smaller and disputed for BRCA1 carriers; up to one-third of BRCA2 mutation carriers are expected to develop prostate cancer before age 65. Prostate cancer in BRCA mutation carriers tends to appear a decade earlier than normal, and it tends to be more aggressive than normal.
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