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Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes. [9] Mutations in the HNF1A gene have been known to cause diabetes. [10] The HNF1A gene also contains a SNP associated with increased risk of coronary artery disease ...
Retinal homeobox protein Rx also known as retina and anterior neural fold homeobox is a protein that in humans is encoded by the RAX gene. [5] The RAX gene is located on chromosome 18 in humans, mice, and rats.
The costs of genetic testing vary depending on the type and complexity of the test. According to health experts, genetic test costs range from $100 to more than $2,000 without coverage.
The POU domain is a bipartite domain composed of two subunits separated by a non-conserved region of 15-55 aa. The N-terminal subunit is known as the POU-specific (POUs) domain (InterPro: IPR000327), while the C-terminal subunit is a homeobox domain (InterPro: IPR007103). 3D structures of complexes including both POU subdomains bound to DNA are available.
The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox). This amino acid sequence folds into a "helix-turn-helix" (i.e. homeodomain fold) motif that is stabilized by a third helix.
71950 Ensembl ENSG00000111704 ENSMUSG00000012396 UniProt Q9H9S0 Q80Z64 RefSeq (mRNA) NM_001297698 NM_024865 NM_028016 NM_001289828 NM_001289830 NM_001289831 RefSeq (protein) NP_001284627 NP_079141 NP_001276757 NP_001276759 NP_001276760 NP_082292 Location (UCSC) Chr 12: 7.79 – 7.8 Mb Chr 6: 122.68 – 122.69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein NANOG ...
The homeotic selector genes were discovered through the genetic analysis of Drosophila over 80 years ago [citation needed].Unusual disturbances were found in the organization of the adult fly, resulting in misplaced limbs, such as legs developing where antennae usually develop or an extra pair of wings developing where halteres should be.
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