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  2. Sildenafil - Wikipedia

    en.wikipedia.org/wiki/Sildenafil

    Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [11] It was approved for medical use in the United States and in the European Union in 1998. [ 5 ] [ 8 ] [ 11 ] [ 12 ] In 2022, it was the 157th most commonly prescribed medication in the United States, with more than 3 million prescriptions.

  3. Things You Probably Don't Know About Viagra (Like What ... - AOL

    www.aol.com/things-probably-dont-know-viagra...

    Viagra has made its way into medicine cabinets the world over as a trusted medication for ED and cardiovascular health. We know intimate activity is supposed to be somewhat off the cuff, but you ...

  4. cGMP-specific phosphodiesterase type 5 - Wikipedia

    en.wikipedia.org/wiki/CGMP-specific_phosphodi...

    Bulk bag of counterfeit Viagra. Sildenafil (marketed as Viagra) was the first PDE5 inhibitor on the market. Originally created as a treatment for high blood pressure in 1989, it was found to have a secondary use as an effective PDE5 inhibitor, enabling men who use it to gain stronger erections after arousal.

  5. Pfizer - Wikipedia

    en.wikipedia.org/wiki/Pfizer

    The enzyme Dr. Simmons claims to have discovered would induce pain and inflammation while causing gastrointestinal problems and Celebrex is used to reduce those issues. A six-year battle ensued because BYU claimed that Pfizer did not give Dr. Simmons credit or compensation, while Pfizer claimed that it had met all obligations regarding the ...

  6. Your ED Pill Guide: Everything You Need to Know Before ... - AOL

    www.aol.com/ed-pill-guide-everything-know...

    Whether you’re one of the 30 million men who have (ED) or not, you’ve almost certainly heard of Viagra. Maybe you even know about other ED medications, like Levitra or Stendra or Cialis, too.

  7. What Happens If You Take Viagra and You Don't Need It? - AOL

    www.aol.com/happens-viagra-dont-105800158.html

    Recreational Viagra use does happen, and while some men see harmless benefits from the active ingredient in the famous “little blue pill,” they’re still taking a significant risk every time ...

  8. PDE5 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE5_inhibitor

    Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

  9. 22 Ways Men Can Make Their Orgasms Better - AOL

    www.aol.com/23-ways-men-orgasms-better-211300041...

    Here’s a fun fact, actually: According to Johnson, the main active ingredients of erectile dysfunction medications Cialis and Viagra—tadalafil and sildenafil—work by lowering blood pressure.