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DNA nanotechnology, specifically, is an example of bottom-up molecular self-assembly, in which molecular components spontaneously organize into stable structures; the particular form of these structures is induced by the physical and chemical properties of the components selected by the designers. [19]
Nucleic acid design is used in DNA nanotechnology to design strands which will self-assemble into a desired target structure. These include examples such as DNA machines, periodic two- and three-dimensional lattices, polyhedra, and DNA origami. [2]
For example, when using atomic or ionic building blocks in the construction of materials, the crystal structure, symmetry, and spacing are fixed by atomic radii and electronegativity. However, in the nanoparticle-based system, crystal structure can be tuned independent of the nanoparticle size and composition by simply adjusting the length and ...
As a nucleic acid structure, i-motif DNA stability is dependent on the nature of the sequence, temperature, and ionic strength. The structural stability of i-motif DNA is mainly reliant on the fact that there is minimal overlap between the six-membered aromatic pyrimidine bases due to the consecutive base pairs' intercalative geometry.
The term has also been used to describe the hierarchical assembly of artificial nucleic acid building blocks used in DNA nanotechnology. [3] The quaternary structure of DNA refers to the formation of chromatin. Because the human genome is so large, DNA must be condensed into chromatin, which consists of repeating units known as nucleosomes.
This is an accepted version of this page This is the latest accepted revision, reviewed on 18 December 2024. Manipulation of an organism's genome For a non-technical introduction to the topic of genetics, see Introduction to genetics. For the song by Orchestral Manoeuvres in the Dark, see Genetic Engineering (song). For the Montreal hardcore band, see Genetic Control. Part of a series on ...
A nanostructure is a structure of intermediate size between microscopic and molecular structures. Nanostructural detail is microstructure at nanoscale . In describing nanostructures, it is necessary to differentiate between the number of dimensions in the volume of an object which are on the nanoscale .
The method of DNA origami was developed by Paul Rothemund at the California Institute of Technology. [6] In contrast to common top-down fabrication methods such as 3D printing or lithography which involve depositing or removing material through a tool, DNA Nanotechnology, as well as DNA Origami as a subset, is a bottom-up fabrication method.