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Sarcopenia (ICD-10-CM code M62.84 [1]) is a type of muscle loss that occurs with aging and/or immobility. It is characterized by the degenerative loss of skeletal muscle mass, quality, and strength. The rate of muscle loss is dependent on exercise level, co-morbidities, nutrition and other factors.
Society on Sarcopenia, Cachexia and Wasting Disorders (SCWD) is an international and multidisciplinary non-profit organization, created in 2008 that focuses on cachexia [1] and sarcopenia. [2] As they are often under-diagnosed, patient groups aim to improve their awareness. [ 3 ]
Sarcopenic obesity is a combination of two disease states, sarcopenia and obesity. Sarcopenia is the muscle mass/strength/physical function loss associated with increased age, [ 1 ] and obesity is based off a weight to height ratio or body mass index (BMI) that is characterized by high body fat or being overweight.
Sarcopenia can lead to reduction in functional status and cause significant disability but is a distinct condition from cachexia although they may co-exist. [ 8 ] [ 11 ] In 2016 an ICD code for sarcopenia was released, contributing to its acceptance as a disease entity.
Sarcopenia is the degenerative loss of skeletal muscle mass, quality, and strength associated with aging. [14] The rate of muscle loss is dependent on exercise level, co-morbidities, nutrition and other factors. Sarcopenia can lead to reduction in functional status and cause significant disability from increased weakness. The muscle loss is ...
The Journal of Cachexia, Sarcopenia and Muscle is a quarterly peer-reviewed medical journal that covers research relevant to changes in body composition, especially cachexia and sarcopenia, as consequences of chronic illnesses or of the aging process, respectively.
Myostatin inhibitors were generally able to increase lean body mass and reduce body fat in people with sarcopenia, but the extent to which this translated into functional improvements varied. [11] Bimagrumab showed effectiveness in increasing lean mass and reducing fat mass in obese individuals in a clinical trial. [11]
Identification, treatment, and research of cachexia have historically been limited by the lack of a widely accepted definition of cachexia. In 2011, an international consensus group adopted a definition of cachexia as "a multifactorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that can be partially but not entirely reversed by conventional ...