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Only one type of light chain is present in a typical antibody, thus the two light chains of an individual antibody are identical. Each light chain is composed of two tandem immunoglobulin domains: one constant (C L) domain; one variable domain (V L) that is important for binding antigen; The approximate length of a light chain protein is from ...
Single chain variable fragments and Fab fragments also bind to protein L. Despite this wide binding range, protein L is not a universal antibody-binding protein. Protein L binding is restricted to those antibodies that contain kappa light chains.
The variable region of light is therefore encoded by the rearrangement of VJ segments. The light chain can be either kappa,κ or lambda,λ. This process takes place at the level of mRNAs processing. Random rearrangements and recombinations of the gene segments at DNA level to form one kappa or lambda light chain occurs in an orderly fashion.
The kappa (κ) and lambda (λ) chains of the immunoglobulin light chain loci rearrange in a very similar way, except that the light chains lack a D segment. In other words, the first step of recombination for the light chains involves the joining of the V and J chains to give a VJ complex before the addition of the constant chain gene during ...
The chromosomal region that encodes an antibody is large and contains several distinct gene loci for each domain of the antibody—the chromosome region containing heavy chain genes is found on chromosome 14, and the loci containing lambda and kappa light chain genes (IGL@ and IGK@) are found on chromosomes 22 and 2 in humans. One of these ...
n/a Ensembl ENSG00000211592 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 2: 88.86 – 88.86 Mb n/a PubMed search n/a Wikidata View/Edit Human Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains for antibodies. It is found on chromosome 2, in humans, within the Immunoglobulin ...
Anti-Kappa Light Chain Type Description; Anti-Kappa Light Chain [NH3/41.34] This is a recombinant monoclonal antibody to the kappa light chain. Specifically, [NH3/41.34] binds to IgG antibodies via Western blot. There is no cross reactivity with cynomolgus monkey IgG1 and cynomolgus monkey IgG4, which are recognized by Anti-IgG [NH3/130.5.2]. [23]
Immunoglobulin kappa locus, also known as IGK@, is a region on the p arm of human chromosome 2, region 11.2 (2p11.2), that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins). [2] In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region. [3]
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