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The variation has led to the suggestion that treatment responsive and treatment resistant schizophrenia be considered as two different subtypes. [149] [159] It is further suggested that if the subtypes could be distinguished at an early stage significant implications could follow for treatment considerations, and for research. [154]
She founded the first scientific data to suggest that patients with treatment resistant schizophrenia do not have dopaminergic abnormality, and that the majority of these patients do not respond to treatment from the initial phases of their illness. [4] She has also won a Scholarship Award for Best Article in 2022 (Editors’ Choice). [5]
The effectiveness of xanomeline/trospium chloride for the treatment of schizophrenia in adults was evaluated in two studies with identical designs. [2] Study 1 (NCT04659161) and study 2 (NCT04738123) were 5-week, randomized, double-blind, placebo-controlled, multi-center studies in adults with a diagnosis of schizophrenia according to DSM-5 ...
Antipsychotic drug treatment is a key component of schizophrenia treatment recommendations by the National Institute of Health and Care Excellence (NICE), [23] the American Psychiatric Association, [24] and the British Society for Psychopharmacology. [25]
Clozapine is an effective treatment for those who respond poorly to other drugs ("treatment-resistant" or "refractory" schizophrenia), [142] but it has the potentially serious side effect of agranulocytosis (lowered white blood cell count) in less than 4% of people. [132] [143] [144] Most people on antipsychotics get side effects.
ECT is widely used worldwide in the treatment of schizophrenia, but in North America and Western Europe it is invariably used only in treatment resistant schizophrenia when symptoms show little response to antipsychotics; there is comprehensive research evidence for such practice. [55]
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