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Aziridine is an organic compound consisting of the three-membered heterocycle C 2 H 5 N. [ 5 ] [ 6 ] It is a colorless, toxic, volatile liquid that is of significant practical interest. [ 7 ] Aziridine was discovered in 1888 by the chemist Siegmund Gabriel . [ 8 ]
Mitomycin C, an aziridine, is used as a chemotherapeutic agent by virtue of its antitumour activity. [1]In organic chemistry, aziridines are organic compounds containing the aziridine functional group (chemical structure (R−) 4 C 2 N−R), a three-membered heterocycle with one amine (>NR) and two methylene bridges (>CR 2).
Polyethylenimine (PEI) or polyaziridine is a polymer with repeating units composed of the amine group and two carbon aliphatic CH 2 CH 2 spacers. Linear polyethyleneimines contain all secondary amines, in contrast to branched PEIs which contain primary, secondary and tertiary amino groups.
The Blum–Ittah aziridine synthesis, also known as the Blum–Ittah-Shahak aziridine synthesis [1] or simply the Blum aziridine synthesis is a name reaction of organic chemistry, for the generation of aziridines from oxiranes.
Pages in category "Aziridines" The following 13 pages are in this category, out of 13 total. This list may not reflect recent changes. ...
The Wenker synthesis is an organic reaction converting a beta amino alcohol to an aziridine with the help of sulfuric acid. It is used industrially for the synthesis of aziridine itself. [1] Wenker synthesis. The original Wenker synthesis of aziridine itself takes place in two steps.
The aza-Payne rearrangement may be effected in either the "forward" (epoxide to aziridine) or "reverse" (aziridine to epoxide) direction depending on the conditions employed. Electron-poor aziridines undergo the reverse rearrangement in the presence of hydride base, [ 13 ] while the corresponding epoxy amines undergo the forward rearrangement ...
Alternatively, they can be obtained by oxidation of the corresponding aziridine. Azirine can be generated during photolysis of isoxazole. [ 3 ] Due to the weak N-O bond, the isoxazole ring tends to collapse under UV irradiation, rearranging to azirine.