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The variation has led to the suggestion that treatment responsive and treatment resistant schizophrenia be considered as two different subtypes. [149] [159] It is further suggested that if the subtypes could be distinguished at an early stage significant implications could follow for treatment considerations, and for research. [154]
Evenamide (INN Tooltip International Nonproprietary Name) (developmental code names NW-3509, NW-3509A) [1] is a selective voltage-gated sodium channel blocker, including (and not limited to) subtypes Na v 1.3, Na v 1.7, and Na v 1.8, which is described as an antipsychotic and is under development by Newron Pharmaceuticals as an add-on therapy for the treatment of schizophrenia.
Clozapine is an effective treatment for those who respond poorly to other drugs ("treatment-resistant" or "refractory" schizophrenia), [94] but it has the potentially serious side effect of agranulocytosis (lowered white blood cell count) in less than 4% of people. [95]
Schizophrenia presents significant challenges, but with diagnosis, treatment, and support, individuals can manage symptoms and lead fulfilling lives.
Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...
The primary treatment of schizophrenia is the use of antipsychotic medications, often in combination with psychosocial interventions and social supports. [ 27 ] [ 185 ] Community support services including drop-in centers, visits by members of a community mental health team , supported employment , [ 186 ] and support groups are common.
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