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The primary treatment of schizoaffective disorder is medication, with improved outcomes using combined long-term psychological and social supports. [23] Hospitalization may occur for severe episodes either voluntarily or (if mental health legislation allows it) involuntarily.
The variation has led to the suggestion that treatment responsive and treatment resistant schizophrenia be considered as two different subtypes. [ 149 ] [ 159 ] It is further suggested that if the subtypes could be distinguished at an early stage significant implications could follow for treatment considerations, and for research. [ 154 ]
Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
Clozapine is an effective treatment for those who respond poorly to other drugs ("treatment-resistant" or "refractory" schizophrenia), [142] but it has the potentially serious side effect of agranulocytosis (lowered white blood cell count) in less than 4% of people. [132] [143] [144] Most people on antipsychotics get side effects.
It has unparalleled efficacy in the treatment of treatment-resistant schizophrenia. Olanzapine (Zyprexa) – Of the theienobenzodiazepine class of atypical antipsychotics. Used to treat psychotic disorders including schizophrenia, acute manic episodes, and maintenance of bipolar disorder.
Psychosis is noted in Other specified schizophrenia spectrum and other psychotic disorders as a DSM-5 category. Schizoaffective disorder is diagnosed if symptoms of mood disorder are substantially present alongside psychotic symptoms. Psychosis that results from a general medical condition or substance is termed secondary psychosis.
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