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  2. Treatment-resistant depression - Wikipedia

    en.wikipedia.org/wiki/Treatment-resistant_depression

    Ketamine has been tested as a rapid-acting antidepressant [22] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [23] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [24] [25]

  3. Management of depression - Wikipedia

    en.wikipedia.org/wiki/Management_of_depression

    The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...

  4. STAR*D - Wikipedia

    en.wikipedia.org/wiki/STAR*D

    Sequenced Treatment Alternatives to Relieve Depression (STAR*D) was a collaborative study on the treatment of depression, funded by the National Institute of Mental Health. Its main focus was on the treatment of depression in patients where the first prescribed antidepressant proved inadequate.

  5. Psychological resistance - Wikipedia

    en.wikipedia.org/wiki/Psychological_resistance

    The discovery of resistance (German: Widerstand) was central to Sigmund Freud's theory of psychoanalysis: for Freud, the theory of repression is the cornerstone on which the whole structure of psychoanalysis rests, and all his accounts of its discovery "are alike in emphasizing the fact that the concept of repression was inevitably suggested by the clinical phenomenon of resistance". [5]

  6. Directly observed treatment, short-course - Wikipedia

    en.wikipedia.org/wiki/Directly_observed...

    Directly observed treatment, short-course (DOTS, also known as TB-DOTS) is the name given to the tuberculosis (TB) control strategy recommended by the World Health Organization. [1] According to WHO, "The most cost-effective way to stop the spread of TB in communities with a high incidence is by curing it.

  7. Drug resistance - Wikipedia

    en.wikipedia.org/wiki/Drug_resistance

    Drug, toxin, or chemical resistance is a consequence of evolution and is a response to pressures imposed on any living organism. Individual organisms vary in their sensitivity to the drug used and some with greater fitness may be capable of surviving drug treatment.

  8. Dysthymia - Wikipedia

    en.wikipedia.org/wiki/Dysthymia

    Dysthymia (/ d ɪ s ˈ θ aɪ m i ə / dihs-THIY-mee-uh), also known as persistent depressive disorder (PDD), [3] is a mental and behavioral disorder, [5] specifically a disorder primarily of mood, consisting of similar cognitive and physical problems as major depressive disorder, but with longer-lasting symptoms.

  9. Drug of last resort - Wikipedia

    en.wikipedia.org/wiki/Drug_of_last_resort

    Drug resistance, such as antimicrobial resistance or antineoplastic resistance, may make the first-line drug ineffective, especially in case of multidrug-resistant pathogens and tumors. Such an alternative may be outside of extant regulatory requirements or medical best practices, in which case it may be viewed as salvage therapy .