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The results of two different types of analysis revealed a slight acceleration of hippocampal volume loss around age 60–65 years for females, whereas for males the rate of hippocampal volume loss may increase earlier around 50 years (Fig. 7, Fig. 8).
When including age, gender and normalized hippocampal volume as explanatory variables and CVLT-LD as response variable, we calculated the conditional inference tree as depicted in Figure 6a. Gender is shown to be the most influencial variable (Bonferroni adjusted p < 0.001).
A quantitative MR study of the hippocampal formation, the amygdala, and the temporal horn of the lateral ventricle in healthy subjects 40 to 90 years of age. AJNR Am J Neuroradiol. 1999;20 (2):207-211. PubMed Google Scholar. Resnick SM, Goldszal AF, Davatzikos C, et al. One-year age changes in MRI brain volumes in older adults.
Hippocampal volumes measured with both FS and AA were associated with age (p < 0.001). The 5th percentile thresholds, indicating left/right hippocampal atrophy were respectively: (i) below 3,223/3,456 mm 3 at 56 years and 2,506/2,415 mm 3 at 90 years for FS; (ii) below 4,583/4,873 mm 3 at 56 years and 3,831/3,870 mm 3 at 90 years for AA.
In this report, we provide normative values for hippocampal and total grey matter volume as a function of age for reference in clinical and research settings. These normative values may be used in combination with our online, automated percentile estimation tool to provide a rapid, objective evaluation of an individual's hippocampal volume status.
Both, NAA/Cho (r = −0.53, p = 0.01) and NAA/Cr (r = −0.61, p < 0.005) were significantly correlated with age, so was hippocampal volume (r = −0.64, p < 0.005). Over the age range studied, NAA/Cho declined by 24% from a value of 1.66 ± 0.10 (standard error) at the age of 36 to 1.25 ± 0.24 at the age of 85 based on the regression.
While age-related decline in hippocampal volume is well documented, most of our knowledge about hippocampal structure-function relationships was discovered in the context of neurological and neurodegenerative diseases. The relationship between cognitive aging and hippocampal structure in the absence of disease remains relatively understudied.
This study examined the cross-sectional age-related changes and sex differences in hippocampal shape in a multisite, multistudy cohort of 1676 typically developing children (age 1–22 years) using a novel intrinsic brain mapping method based on Laplace–Beltrami embedding of surfaces.
Volume 233, June 2021, 117931. Hippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates. Aurélie Bussy a b. , Eric Plitman a c. , Raihaan Patel a d. , Stephanie Tullo a b. , Alyssa Salaciak a. , Saashi A. Bedford a c. , Sarah Farzin a. , Marie-Lise Béland a. , Vanessa Valiquette a b. ,
In this study of 765 community‐based older people (with a mean age at death of 90 years), we investigated whether the association of atherosclerosis with hippocampal to hemisphere volume ratio is modified by age, sex, blood pressure (BP), diabetes, or apolipoprotein ε4 (APOE ε4).