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Trametinib, sold under the brand name Mekinist among others, is an anticancer medication used for the treatment of melanoma [4] [5] and glioma. [ 6 ] [ 7 ] It is a MEK inhibitor drug with anti-cancer activity. [ 8 ]
Dabrafenib is indicated as a single agent for the treatment of people with unresectable or metastatic melanoma with BRAF V600E mutation. [2] Dabrafenib is indicated, in combination with trametinib, for BRAF V600E-positive unresectable or metastatic melanoma, metastatic non-small cell lung cancer, metastatic anaplastic thyroid cancer, and unresectable or metastatic solid tumors.
The combination of dabrafenib and trametinib was approved for NHS use for youngsters with brain tumours in April. However, Alexander has been accessing the medication privately at a cost of about ...
A phase III trial (vs dacarbazine) in patients with previously untreated metastatic melanoma showed an improved rates of overall and progression-free survival. [18] In June 2011, positive results were reported from the phase III BRIM3 BRAF-mutation melanoma study. [19] The BRIM3 trial reported good updated results in 2012. [20]
Awakenings is a 1973 non-fiction book by Oliver Sacks.It recounts the life histories of those who had been victims of the 1920s encephalitis lethargica epidemic. [1] Sacks chronicles his efforts in the late 1960s to help these patients at the Beth Abraham Hospital (now Beth Abraham Center for Rehabilitation and Nursing) in the Bronx, New York. [2]
A complex plot of body-swapping and time travel ensues. It is considered by some people to be the best story in the collection. [2] "Dumb Martian" [3] a satire on racism, featuring an Earthman who buys a Martian wife. "Compassion Circuit" a horror story on the subject of robotics. "Survival" set on a spacecraft marooned in orbit around Mars.
Unbroken: A World War II Story of Survival, Resilience, and Redemption is a 2010 non-fiction book by Laura Hillenbrand. Unbroken is a biography of World War II veteran Louis Zamperini, a former Olympic track star who survived a plane crash in the Pacific Theater, spent 47 days drifting on a raft, and then survived more than two and a half years as a prisoner of war (POW) in three Japanese POW ...
People who are HIV positive speak about the challenges they face, how dealing with the disease has changed, and their survival stories. As more is being learned and discovered about HIV and AIDS ...